Vamp

VAMP - vesicle-associated membrane protein or synaptobrevin is a small integral membrane protein of secretory vesicle. Its molecular weight is approximately 18 kilodalton (kDa). In mammals, three VAMP isoforms have been described. VAMP-1 and -2 are brain-specific proteins whereas the third isoform, cellubrevin, is expressed ubiquitously.

Related Topics:
Integral membrane protein - Secretory vesicle - Kilodalton

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VAMP is one of the SNARE proteins involved in formation of the SNARE complexes. Out of four helices of a SNARE complex one is contributed by VAMP.

Related Topics:
SNARE proteins - SNARE complexes

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SNARE proteins are believed to be the key components of the molecular machinery that drives fusion of membranes in e.g. exocytosis.

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Due to the fact that all proteins belonging to VAMP/Synaptobrevin family share common structural feature, they have been classified as R-SNAREs. An alternative classification (v- and t-SNAREs) exists that takes into account origin of VAMP-bearing organelle rather than their structural properties

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