Ubiquitin

Ubiquitin is a small protein that occurs in all eukaryotic cells. Its main function is to mark other proteins for destruction, known as proteolysis. Several ubiquitin molecules attach to the condemned protein (polyubiquitination), and it then moves to a proteasome, a barrel-shaped structure where the proteolysis occurs.

Immunohistochemistry

Antibodies to ubiquitin are used in histology to identify abnormal accumulations of protein inside cells that are markers of disease. These accumulations are called inclusion bodies. Examples of such abnormal inclusions in cells are

Related Topics:
Antibodies - Histology

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• Neurofibrillary tangles in Alzheimer's disease
• Lewy body in Parkinson's disease
• Pick bodies in Picks disease
• Inclusions in motor neuron disease
• Mallory's Hyalin in alcoholic liver disease
• Rosenthal fibres in astrocytes