Trazodone

Trazodone is a psychoactive compound with sedative and antidepressant properties. Its mechanism of action in humans is not clear. Trazodone is well absorbed after oral administration with mean peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food. The mean plasma elimination half-life is 4.4 hours for the period from 3 to 10 hours after dosing, and 7 to 8 hours for the period from 10 to 34 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in man. Approximately 60 to 70% of C14-labelled trazodone was found to be excreted in the urine within 2 days and 9 to 29% in feces over 60 to 100 hours. Trazodone is 89 to 95% protein bound in vitro at concentrations attained with therapeutic doses.

Related Topics:
Psychoactive - Sedative - Antidepressant

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