Tramadol

Tramadol is an opioid used as an analgesic for treating moderate to severe pain. It is a synthetic agent, unrelated to other opioids, and appears to have actions on the GABAergic, noradrenergic and serotonergic systems. Tramadol was developed by the German pharmaceutical company Gr?nenthal GmbH and marketed under the trade name Tramal®. Gr?nenthal has also cross licensed the drug to many other pharmaceutical companies that market it under various names, some of which are listed below.

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Tramadol is available in both injectable (intravenous and/or intramuscular) and oral preparations. It is usually marketed as the hydrochloride salt (tramadol hydrochloride). Dosages vary depending on the degree of pain experienced by the patient, and should be decided on the basis of need by the prescriber.

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Opioid: An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. There are four broad classes of opioids: endogenous opioid peptides, produced in the body; opium alkaloids, such as morphine (the prototypical opioid) and codeine; semi-s...

Analgesic: An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia (literally, "absence of pain"). Analgesic drugs act in various ways on the peripheral and central nervous system; they include paracetamol (acetaminophen), the no...

GABAergic: REDIRECT Gamma-Aminobutyric acid...