Spanish flu

The Spanish Flu Pandemic, also known as the Great Influenza Pandemic, the 1918 Flu Epidemic, and La Grippe, was an unusually severe and deadly strain of avian influenza, a viral infectious disease, that killed some 25 million to 50 million people worldwide in 1918 and 1919. It is thought to have been one of the most deadly pandemics so far in human history. It was caused by the H1N1 type of flu virus.

Sources

• {{note|genes}} Special report at Nature News: The 1918 flu virus is resurrected, Published online: 5 October 2005; | doi:10.1038/437794a. See: "Characterization of the 1918 influenza virus polymerase genes" by Jeffery K. Taubenberger, Ann H. Reid, Raina M. Lourens, Ruixue Wang, Guozhong Jin and Thomas G. Fanning in Nature (2005) volume 437 pages 889-893 {{Doi|10.1038/nature04230}}. Also: "Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus" by Terrence M. Tumpey, Christopher F. Basler, Patricia V. Aguilar, Hui Zeng, Alicia Solórzano, David E. Swayne, Nancy J. Cox, Jacqueline M. Katz, Jeffery K. Taubenberger, Peter Palese and Adolfo García-Sastre in Science (2005) volume 310 pages 77-80. {{Doi|10.1126/science.1119392}}
• Terrence M. Tumpey, Adolfo García-Sastre, Andrea Mikulasova, Jeffery K. Taubenberger, David E. Swayne, Peter Palese, and Christopher F. Basler (2002) "Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus". Proceedings of the National Academy of Sciences 99, 13849–13854.
• Alfred W. Crosby (1990). America's Forgotten Pandemic: The Influenza of 1918. Cambridge University Press. ISBN 0521386950.
• John M. Barry, (2004). The Great Influenza: The Epic Story of the Greatest Plague in History. Viking Penguin. ISBN 0670894737.
• Leonard Crane, (2000). Ninth Day of Creation. Connection Books. ISBN 0967571294.
• Andrew Noymer and Michel Garenne (2000). "The 1918 Influenza Epidemic's Effects on Sex Differentials in Mortality in the United States". Population and Development Review, 26(3):565–581.
• Geoffrey W. Rice and Edwina Palmer (1993). "Pandemic Influenza in Japan, 1918–19: Mortality Patterns and Official Responses". Journal of Japanese Studies, 19(2):389–420.