Smallpox


 

Smallpox (also known by the Latin names Variola or Variola vera) is a highly contagious disease unique to humans. It is caused by two virus variants called Variola major and Variola minor. V. major is the more deadly form, with a typical mortality of 20-40 percent of those infected. The other type, V. minor, only kills 1% of its victims. Many survivors are left blind in one or both eyes from corneal ulcerations, and persistent skin scarring - pockmarks - is nearly universal. Smallpox was responsible for an estimated 300-500 million deaths in the 20th century. As recently as 1967, the World Health Organization (WHO) estimated that 15 million people contracted the disease and that two million died in that year.

Related Topics:
Latin - Disease - Virus - 1967

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After successful vaccination campaigns, the WHO in 1979 declared the eradication of smallpox, though cultures of the virus are kept by the Centers for Disease Control and Prevention (CDC) in the United States and at the Institute of Virus Preparations in Siberia, Russia. Smallpox vaccination was discontinued in most countries in the 1970s as the risks of vaccination include death (~1 per million), among other serious side effects. Nonetheless, after the 2001 anthrax attacks took place in the United States, concerns about smallpox have resurfaced as a possible agent for bioterrorism. As a result, there has been increased concern about the availability of vaccine stocks. Moreover, President George W. Bush has ordered all American military personnel to be vaccinated against smallpox and has implemented a voluntary program for vaccinating emergency medical personnel.

Related Topics:
Vaccination - WHO - 1979 - Culture - Centers for Disease Control and Prevention - United States - Institute of Virus Preparations - Siberia - Russia - 1970s - 2001 anthrax attacks - Bioterrorism - President - George W. Bush

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Famous victims of this disease include Ramesses V (see Koplow, p. 11, plus notes), Shunzhi Emperor of China (official history), Mary II of England, Louis XV of France, and Peter II of Russia. Henry VIII's fourth wife, Anne of Cleves, survived the disease but was scarred by it, as was Henry VIII's daughter, Elizabeth I of England in 1562 and Abraham Lincoln in 1863.

Related Topics:
Ramesses V - Shunzhi Emperor - Mary II of England - Louis XV of France - Peter II of Russia - Henry VIII - Anne of Cleves - Elizabeth I - 1562 - Abraham Lincoln - 1863

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After first contacts with Europeans and Africans, the death of a large part of the native population of the New World was caused by Old World diseases. Smallpox was the chief culprit. On at least one occasion, germ warfare was attempted by the British Army under Jeffrey Amherst when two smallpox-infected blankets were deliberately given to representatives of the besieging Delawares Indians during Pontiac's Rebellion in 1763. That Amherst intended to spread the disease to the natives is not doubted by historians; whether or not the attempt succeeded is a matter of debate.

Related Topics:
European - Africans - New World - Old World - Germ warfare - British Army - Jeffrey Amherst - Delaware - Pontiac's Rebellion - 1763 - [details]

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Smallpox is described in the Ayurveda books. Treatment included inoculation with year-old smallpox matter. The inoculators would travel all across India pricking the skin of the arm with a small metal instrument using "variolous matter" taken from pustules produced by the previous year's inoculations. The effectiveness of this system was confirmed by the British doctor J.Z. Holwell in an account to the College of Physicians in London in 1767.

Related Topics:
Ayurveda - Inoculation - London - 1767

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Edward Jenner developed a smallpox vaccine by using cowpox fluid (hence the name vaccination, from the Latin vacca, cow); his first inoculation occurred on May 14, 1796. After independent confirmation, this practice of vaccination against smallpox spread quickly in Europe. The first smallpox vaccination in North America occurred on June 2, 1800. National laws requiring vaccination began appearing as early as 1805. The last case of wild smallpox occurred on September 11th, 1977. One last victim was claimed by the disease in the UK in September 1978, when Janet Parker, a photographer in the University of Birmingham Medical School, contracted the disease and died. A research project on smallpox was being conducted in the building at the time, though the exact route by which Ms. Parker became infected was never fully elucidated.

Related Topics:
Edward Jenner - Smallpox vaccine - Cowpox - May 14 - 1796 - June 2 - 1800 - 1805 - September 11 - 1977 - UK - September - 1978 - Janet Parker - University of Birmingham

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Introduction
Infection
History
See also
References
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Latest news on smallpox

Wiping out the next smallpox

The Internet has had an enormous impact on people's lives around the world in the ten years since Google's founding. It has changed politics, entertainment, culture, business, health care, the environment and just about every other topic you can think of. Which got us to thinking, what's going to happen in the next ten years? How will this phenomenal technology evolve, how will we adapt, and (more importantly) how will it adapt to us? We asked ten of our top experts this very question, and during September (our 10th anniversary month) we are presenting their responses. As computer scientist Alan Kay has famously observed, the best way to predict the future is to invent it, so we will be doing our best to make good on our experts' words every day. - Karen Wickre and Alan Eagle, series editorsIt took more than a village: it took the entire world -- people of all races, countries and religions -- to eradicate smallpox. The final naturally occurring cases of "Variola major" in Bangladesh in 1978 and "Variola minor" in Somalia in 1977 marked the end to a chain of suffering and early death dating back to the Biblical plagues, and to Pharoah Ramses, who died from the very same disease. Since then we have continued to face countless pandemics -- the Black Death, cholera, and now bird flu, SARS, HIV/AIDS and a new generation of zoonotic diseases -- diseases that, often because of changes in population or climate, jump from animals to humans. We can't be sure where the next smallpox will emerge, but we can be sure that it will take an effort larger than any single person or organization to defeat it.Today there are some real heroes working to check off two more diseases from the list. The World Health Organization has led the charge against the highly infectious disease of polio. Along with UNICEF and dozens of NGOs, and millions of national and local health workers, members of Rotary International and volunteers from moms to Mullahs have stepped up to the plate and contained polio so that hundreds, not millions, of kids are paralyzed annually, but we cannot consider the case closed until we erase the last case, in the last country. The Carter Center has also accomplished a tremendous feat by leading the effort to shrink the cases of Guinea worm to the tens of thousands from the millions. Just as it took 150,000 health workers -- the world's unsung heroes -- to make one billion house calls in India searching for hidden cases of smallpox, it will take collaboration on a global scale to track and eliminate the next pandemic.There is no Nobel Prize for "Preventing a Pandemic," and the hardest part about working in this field is imagining the unimaginable. What will be the next SARS, the next ebola, the next H5N1 bird flu? Epidemiologists try to "out think" the massive numbers of permutations and combinations that may give rise to the newest threat to our lives. Chances are a microbe capable of sweeping the globe will emerge in the next decade or two, and chances are it will cross to humans from an animal host (as did SARS, the Spanish flu, and HIV/AIDS). We need new ways to find these emerging threats earlier in the process, before thousands are infected and the epidemic spirals out of control.Google.org's Predict and Prevent initiative is working with partners to use digital, genomic and IT technology to identify "hot spots" of emerging threats and provide early warning before they become global crises. When you're fighting a pandemic, early detection and early response can be the difference between dozens and hundreds of millions infected. What better birthday present could we offer the world after our 20th year, than to say we joined hands with a global movement and helped prevent the next smallpox?Posted by Dr. Larry Brilliant, Google.org

Eradication

The battle against disease 30 years after smallpox

China's neo-con nationalist youngsters go online

Fred sez, "This week's New Yorker feature article explores how Chinese nationalism is on the rise despite the proliferation of the internet and so-called "democratizing technologies" that many thought would help Chinese citizens break free of their country's tyranny. The author, Evan Osnos, is answering questions and comments on The New Yorker's website." "Nicholas Negroponte, the founder of M.I.T.?s Media Laboratory and one of the early ideologists of the Internet, once predicted that the global reach of the Web would transform the way we think about ourselves as countries. The state, he predicted, will evaporate ?like a mothball, which goes from solid to gas directly,? and ?there will be no more room for nationalism than there is for smallpox.? In China, things have gone differently." ... "In the anonymity of the Web, decorum deteriorated. ?People who fart through the mouth will get shit stuffed down their throats by me!? one commentator wrote, in a forum hosted by a semi-official newspaper. ?Someone give me a gun! Don?t show mercy to the enemy!? wrote another. The comments were an embarrassment to many Chinese, but they were difficult to ignore among foreign journalists who had begun receiving threats. (An anonymous letter to my fax machine in Beijing warned, ?Clarify the facts on China . . . or you and your loved ones will wish you were dead.?)" Link...

Superbug in hospital outbreak 'has same death rate as smallpox'

EXPERTS fear the strain of Clostridium difficile that has killed eight people at the Vale of Leven Hospital, and been involved in the deaths of eight more, is as deadly as sma

What would you do if you ended up in the year 1000?

The Marginal Revolution blog poses the musical question, "If you were transported back to the middle ages, what would be the top strategy for thriving?" Given that most of us can't make gunpowder from scratch (and don't have up-to-date smallpox vaccinations), dreams of becoming a technological pre-Enlightenment billionaire guru are probably not realistic (stipulating that "realistic" is probably not a good word to use in respect of responses to hypothetical time-travel questions). First build grubstake by minstrelsy. I hope you remember some three chord Stones songs, or perhaps some blues. Next, I would suggest the magic of fractional reserve banking in a market town. Expand the banking operations to other market towns. Hire bodyguards. Loan money to the king. Loan money to the other king. Start a war. Loan money to the Pope, etc. Posted by: Rebunga at Jun 6, 2008 12:15:47 PM Link...