Septum pellucidum

The septum pellucidum, also called the septum lucidum, is a thin, triangular, vertical membrane that separates the lateral ventricles of the brain.

Related Topics:
Lateral ventricle - Brain

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The septum pellucidum actually consists of two layers or laminae of both white and gray matter, called the laminae septi pellucidi. These layers are normally fused; however, in approximately one-tenths of humans, there is a slit-like cavity between them. This space is occasionally called the fifth ventricle, although is usually not continuous with the ventricular system and does not contain cerebrospinal fluid.

Related Topics:
White - Gray matter - Fifth ventricle - Cerebrospinal fluid

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The septum pellucidum is located in the midline of the brain, between the two cerebral hemispheres. It is attached superiorly (above), anteriorly (in front), and inferiorly (below) to the corpus callosum, the large collection of nerve fibers that connect the two hemispheres. Inferiorly and posteriorly (in back), it is attached to the anterior part of the fornix. On either side are the two lateral ventricles, pockets of cerebrospinal fluid within the cerebral hemispheres.

Related Topics:
Cerebral hemisphere - Superiorly - Corpus callosum - Fornix

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Absence of the septum pellucidum or corpus callosum, caused by mutations in the HESX1 gene, is associated with septo-optic dysplasia. This may result in hypothalamic dysfunction and hypopituitarism, as well as problems of vision, coordination, and intelligence, among other abnormalities.

Related Topics:
Mutation - Gene - Septo-optic dysplasia - Hypothalamic - Hypopituitarism

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One famous reference to an abnormality of the septum pellucidum would be the movie Rocky V. In the movie, the main character Rocky Balboa is forced to retire due to brain damage sustained throughout his career.

Related Topics:
Rocky V - Rocky Balboa

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