Reserpine

Reserpine is a an indole alkaloid antipsychotic and antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as dopamine, norepinephrine, and serotonin. This leads to depletion of the neurotransmitters and subsequent depression in humans.

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Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), and introduced in 1954, two years after chlorpromazine.

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Alkaloid: An alkaloid is a nitrogenous organic molecule that has a pharmacological effect on humans and animals. The name derives from the word alkaline; originally, the term was used to describe any nitrogen-containing base (an amine in modern terms). Alkaloids are found as secondary metabolites in plants (e...

Antipsychotic: The term antipsychotic is applied to a group of drugs used to treat psychosis. Common conditions with which antipsychotics might be used include schizophrenia, mania and delusional disorder, although antipsychotics might be used to counter psychosis associated with a wide range of other diagnoses. A...

Antihypertensive: Antihypertensives are a class of drugs that are used In medicine and pharmacology to treat hypertension....