Pseudoephedrine

Pseudoephedrine is a sympathomimetic amine commonly used as a decongestant. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen.

Misuse and illicit use

There have also been reports of off-label uses of pseudoephedrine for its stimulant properties. Some patients, long-distance truck drivers for example, have reportedly used pseudoephedrine as a stimulant to increase their state of alertness/awakedness. It is doubtful that pseudoephedrine would be of significant benefit, except in sensitive-individuals, due to its minimal effect in the central nervous system (see Mode of Action above). Nevertheless, such misuse of pseudoephedrine has been associated with stimulant dependence.

Related Topics:
Central nervous system - Dependence

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The similarity in chemical structure to the amphetamines has made pseudoephedrine a sought-after chemical precursor in the illicit manufacture of methamphetamine and methcathinone. U.S. federal law prohibits buying cold preparations containing pseudoephedrine in quantities greater than 3 packages in any 24-hour period. Individual states also have varying laws on the matter. Various other legislatures around the world similarly restrict the sale of pseudoephedrine-containing products. Internationally, pseudoephedrine is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substanceshttp://www.incb.org/pdf/e/list/red.pdf.

Related Topics:
Amphetamine - Illicit manufacture - Methamphetamine - Methcathinone - Federal law - United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances

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