Protein-protein docking

Protein-protein docking is a field of theoretical biochemistry aimed at predicting properties of the complexes formed by two or more proteins. Specifically, for any given set of proteins, it aims to answer the following questions:

Related Topics:
Protein-protein docking - Biochemistry - Complexes - Proteins

~ ~ ~ ~ ~ ~ ~ ~ ~ ~

• Do the proteins bind in vivo?

:If they bind,

~ ~ ~ ~ ~ ~ ~ ~ ~ ~

:*What is the spatial configuration which they adopt in their bound state?

~ ~ ~ ~ ~ ~ ~ ~ ~ ~

:*How strong or weak is their interaction?

~ ~ ~ ~ ~ ~ ~ ~ ~ ~

The field of protein-protein docking is highly computationally oriented, and it shares approaches with molecular docking. Molecular docking is sometimes referred to as small-molecule docking, to draw a distinction from protein-protein docking. Proteins complexed with polynucleotide molecules are widely studied using similar or identical approaches to protein-protein docking, although if the nucleotide molecule is small enough, the case may be framed as a molecular docking problem.

Related Topics:
Molecular docking - Polynucleotide - Protein-protein docking

~ ~ ~ ~ ~ ~ ~ ~ ~ ~

 
Protein-protein docking: Generating putative complex structures ►