Proteasome

Ubiquitin proteasome system or ubiquitin-26S proteasome system, is a barrel-shaped multi-protein complex that can specifically digest other proteins into short polypeptides and amino acids in an ATP-driven reaction. The Ubiquitin proteasome system is essential for many cellular processes including cell cycle, signal transduction and regulation of gene expression. The importance of proteolytic degradation inside cells and the role of ubiquitin in proteolytic pathways was acknowledged in the awarding of the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose.

Related Topics:
Ubiquitin - Proteasome - Protein - Polypeptide - Amino acid - ATP - Cellular - Cell cycle - Signal transduction - Gene expression - 2004 - Nobel Prize in Chemistry - Aaron Ciechanover - Avram Hershko - Irwin Rose

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