Placenta
The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy).
Related Topics:
Placental - Mammals - Gestation - Pregnancy
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The placenta is composed of two parts, one of which, the chorion, is genetically and biologically part of the fetus, the other part of the mother. It is implanted in the wall of the uterus, where it receives nutrients from the mother's blood and passes out waste. This interface forms a barrier, the placental barrier, which filters out many substances which could harm the fetus. However, many other substances are not filtered out, including alcohol. Most viruses also easily cross this barrier.
Related Topics:
Chorion - Fetus - Uterus - Blood - Alcohol - Virus
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In addition to the transfer of gases and nutrients, the placenta also has metabolic and endocrine activity. It produces, amongst other hormones, progesterone which is important in maintaining the pregnancy, and somatomammotropin (also known as Placental Lactogen) which acts to increase the amount of glucose and lipids in the maternal blood. This results in increased transfer of these nutrients to the fetus and is also the main cause of the increased blood sugar levels seen in pregnancy.
Related Topics:
Endocrine - Hormones - Progesterone - Somatomammotropin
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The placenta is connected to the fetus via the umbilical cord which is composed of blood vessels and connective tissue. When the fetus is delivered, the placenta is delivered afterwards (and for this reason is often called the afterbirth). After delivery of the placenta the umbilical cord is usually clamped and severed or may be left attached to fall off naturally which is referred to as a Lotus Birth. In most mammalian species, the mother bites the cord and consumes the placenta.
Related Topics:
Umbilical cord - Lotus Birth
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Some gynecologists in England claim that they have witnessed the practice of placenta consumption amongst humans in hospital wards in the 1990's (Lieberman, Dr. Telephone interview. University of London undergraduate assignment. 1999. London England).
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The relationship between the mother and foetus is to some extent antagonistic. It is largely in the foetus's interest to draw more resources from the mother: the mother only shares half her genes with the foetus, so although they have a mutual interest in the success of the foetus, the antagonistic balance can be upset if, for example, the placenta over or under produces certain hormones.
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The site of the former umbilical cord attachment in the center of the front of the abdomen is known as the umbilicus, or navel, or belly-button.
Related Topics:
Abdomen - Umbilicus
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The only non-placental mammals are the monotremes, which are egg-laying mammals found only in Australia and New Guinea. Marsupials, which are found primarily in Australia, have a rudimentary egg-yolk placenta, which degenerates quite early in foetal development. Both marsupials and monotremes represent earlier branching of the basal mammalian lineage.
Related Topics:
Monotreme - Australia - New Guinea - Marsupial
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Latest news on placenta
Unborn babies fight back against malaria infection
Malarial infections of the placenta put millions of babies at risk, but some fetuses have found a way to combat the disease
Media cite anti-abortion activist and Obama critic Jill Stanek as though she's credible
Several media outlets have quoted or cited criticism of Sen. Barack Obama by anti-abortion activist and WorldNetDaily columnist Jill Stanek over Obama's opposition to certain bills amending the Illinois Abortion Law of 1975 while he was in the Illinois state Senate -- without citing relevant facts that undermine her credibility. These facts include her suggestion that domestic violence is acceptable against women who have abortions, her support of billboards in Tanzania with the words "Faithful Condom User" next to a picture of a large skeleton, which aimed to discourage condom use there in favor of abstinence and "be[ing] faithful," and her citation of a report that "aborted fetuses are much sought after delicacies" in China to which she added, "I think this stuff is happening." The New York Times, The Associated Press, Fox News' Hannity & Colmes, The New York Sun and The Hill have all quoted Stanek or referred to her in news reports about Obama's opposition to the bills, which Obama said posed a threat to abortion rights and has said were unnecessary because Illinois law already prohibited the conduct being addressed. News reports variously identified Stanek as a nurse, as an anti-abortion activist, as a WorldNetDaily columnist, as someone who "spearheaded" the Born-Alive Infants Protection Act, and as a nurse who testified before the Illinois state Senate's Health and Human Services Committee chaired by Obama "after witnessing a live infant discarded and left to die at the hospital where she worked." But in none of these cases did they cite any of the following: In a March 31 post to her website, titled "Faithful Condom Users Die," Stanek urged her readers to fund Human Life International's (HLI) efforts to post billboards in Tanzania with the words "Faithful Condom Users" next to a picture of a large skeleton, stating, "HLI needs donations to keep the billboards up. Donate here." HLI describes itself as a "pro-life, pro-family, pro-woman organization" that claims as its mission to "fight the evils of abortion, contraception, sex education and family breakdown." In an March 1, 2007, WorldNetDaily column, during a discussion of a scene in the film The Godfather: Part II in which Al Pacino's character hits his wife after she told him she aborted their child, Stanek wrote: "That spontaneous slap was the reaction of a real man who a woman had just told she aborted his baby. Compare that to the modern day cowardly male response, 'It's your choice. Whatever you decide, I'll support you.' " In an April 9, 2007, posts to her website and the Illinois Review blog, Stanek wrote: "The following, if true, is what abortion and the dehumanization of preborn babies has wrought. It is the most despicable outcome of abortion I have ever seen or reported. Yet, if one is 'pro-choice' and denies that preborn humans are human, there is nothing wrong with this whatsoever. It can't even be considered cannibalism." She then cited a March 29, 2007, Epoch Times article, which reported: "The Next Magazine, a weekly publication from Hong Kong, reported that infant corpses and fetuses have become the newest supplements for health and beauty in China. Not only is the placenta considered a beauty remedy, but also aborted fetuses are much sought after delicacies. In Guangdong, gourmet body parts are in high demand and can even be purchased through hospitals..." After a reader questioned the truth of the claims, Stanek wrote: "[A]ccording to Wikipedia, The Epoch Times is an anti-Chinese-government newspaper. Wikipedia compares The Next Magazine, from whence Epoch got its information, to a sensationalist type paper. That said, Wikipedia is accessible by all to skew, including the Chinese government. And there are good sensationalist news organizations, like Drudge (and even the Enquirer these days), and bad sensationalist rags that boast alien abductions on their front page. But I've read legitimate news stories of the Chinese doing strange things with embryos. So I think this stuff is happening. And that last photo in particular looks real" [emphasis added]. In a June 30, 2007, post to her website about the National Education Association's "inexplicable support of abortion," Stanek wrote: "Teachers certainly see abused kids, hungry kids, neglected kids, poor kids. So the NEA's logic is to help kill these problem kids before they're born? That's the same logic of many pro-aborts, both self-serving and lazy." In her November 7, 2007, WorldNetDaily column, Stanek wrote that Barbara Bush, wife of former President George H.W. Bush, was "a pro-abort," adding that her "platform as first lady was illiteracy, so she obviously thought abortion was a solution to illiteracy. In actuality, then, she was a eugenicist, because it is poor people who are illiterate, not rich people." In a February 6, 2007, Illinois Review post called "Debbie Does...??" Stanek noted that Illinois state Senate majority leader Debbie Halvorson had disclosed her human papillomavirus (HPV) status, stated that "you would think she'd focus on her behavior that caused her to contract that sexually transmitted disease" [underline in original], then criticized Halvorson for not disclosing the "number of sex partners she has had," "whether it was her husband who passed HPV on to her after sleeping with other women," or "if Halvorson contracted HPV through rape, [in which case] she could discuss ways to avoid rape." In a February 20, 2007, Illinois Review post discussing Illinois state Rep. John Fritchey's introduction of a bill that would allow a judicial exception to the state's law requiring parental notification before a minor obtains an abortion, Stanek wrote that Fritchey "is now working toward his Teen Genocide Promotion award." Blogger Larry Handlin noted several of Stanek's controversial statements on Archpundit.com. Stanek has also repeatedly made the false claim that Sen. Barack Obama "supports infanticide." Additionally, Hannity & Colmes and The New York Sun each referred to Stanek's allegations that babies that were born despite attempted abortions were abandoned without treatment in the Illinois hospital where she worked -- including in a soiled utility room -- without noting that the Illinois Department of Public Health reportedly said that the alleged conduct, if proved, would have constituted "violations of existing law" but that it could not substantiate the allegation. From the August 18 edition of Fox News' Hannity & Colmes: HANNITY: The abortion issue continues to hamper Barack Obama months after Democratic rival Hillary Clinton challenged his support for Roe v. Wade. Now, according to the New York Sun, pro-life advocates are calling his abortion stance extremism. At issue is Senator Obama's vote against an Illinois law that would have protected infants born alive after a botched abortion procedure. Joining us now, syndicated columnist Ann Coulter, radio show talk show host -- he's nationally syndicated -- Dennis Prager; and former Democratic pollster Pat Caddell. Ann Coulter, I'll start with you. The Born Alive Infant Protection Acts. They induce these abortions. I -- COULTER: Right. HANNITY: I interviewed Jill Stanek. She's a nurse. Illinois. COULTER: Right. HANNITY: Testified before Obama's committee. A baby with Down syndrome aborted, thrown in a soiled utility room. She cradles this baby that's breathing for 45 minutes, and Barack Obama was the only senator to speak out against a bill that would have protected babies in that situation. Is that the -- COULTER: Right. HANNITY: Is that infanticide? COULTER: It's shocking. HANNITY: It is. COULTER: It's -- of course it's infanticide. Yeah, he's for a woman's right to choose through the fourth trimester. And even Barbara Boxer, whom until now was the most staunchly pro-abortion senator, even she spoke in favor of this bill. I mean, this is a child that is not bothering the woman anymore, is not going to make her depressed or affect her health. It's out of the woman's body. They tried to kill it, but somehow the baby made it out alive. From the August 19 edition of Fox News' Hannity & Colmes: HANNITY: Andrea, here's the point. Jill Stanek, who I interviewed, testified before his committee these babies are born alive. She found one in a soiled utility room in the hospital, a Down syndrome baby that was aborted. She cradled and rocked this baby for 45 minutes. He was unfazed, she says, by the testimony when she gave it to him before his committee. How could -- this is so -- this is infanticide.
Injured? Horsing Around With Stem Cells May Get You Back in the Saddle
Doctors might soon be able to regrow injured muscles, tendons and bones without invasive surgery, simply by injecting a person's own stem cells into the site of an injury. Veterinarians are already doing it with injured horses, and research into human applications is well under way. The National Institutes for Health seem to think regenerating human muscle and bone using a person's own adult stem cells is nearly ready for prime time. Last week, the NIH announced to its staff that it's creating a bone marrow-stem cell transplant center within the National Institute for Arthritis and Musculoskeletal and Skin Diseases. Researchers at the NIH labs in Bethesda, Maryland, are already growing human muscle, cartilage and spinal disks in vitro. The tissue isn't mechanically sound yet, says lead researcher Rocky Tuan, but that will come with further work. "I have a piece of tissue that looks like a spinal disc, a sand bag, tough as nails on the outside and like sand on the inside," says Tuan, a Ph.D. and the senior investigator in the Cartilage and Orthopedics branch of the NIAMS. "The mechanical properties are lousy, but it's a beginning." While the use of stem cells harvested from human embryos has been getting the most media attention, scientists and doctors have also been working with adult stem cells that also have the ability to become one with their environment and to replicate as cells of their adopted tissue. Using adult stem cells -- grown inside the body or in the lab -- has become accepted in the veterinary community, and horses have benefited greatly. Researchers are working to bring those same benefits to humans, but there are still hurdles left to clear. The NIH project comes in part from what veterinarians have learned from injecting adult stem cells into valuable horses who've suffered injuries. In many cases, those horses' careers were saved when the stem cells regrew damaged tendons and ligaments. Rodrigo Vazquez, a Southern California veterinarian, has been using adult stem cells to regrow damaged muscles in horses for several years. It's a fairly common procedure in the veterinary arena, and the results are impressive: One of Vazquez's patients is participating in this year's Olympics Dressage events; another is a prize-winning jumper. The procedure is simple and straightforward. Inside a surgical suite at his equine hospital, Vazquez removes blood full of adult stem cells from the sternum of the anesthetized horse. Then he rolls his stool to the other end of the horse, where ultrasound data has helped guide needles into the exact areas on the rear leg where the beautiful horse's ligaments are torn. He injects the stem cells into those spots. "A few years ago, these injuries were career-ending," Vazquez says. Not any more. "In a month, the torn tissue will be completely regrown and healed." Vazquez would like to put himself in his patients' place. He has had surgery several times for spinal injuries he incurred while lifting horses. Human medicine, unable to regrow or heal the injured spine, simply fuses the bone and tissue through a surgical procedure. At best, the surgery relieves some of the pain and restores some mobility. But it's not a true repair. "I wish I could have had a procedure like this," Vazquez says of the treatment he gives horses. "This will lead to human treatments, but they can't move as fast as we can." Tuan, who is using stem cells to cultivate experimental tendons and disks in his lab, thinks it's about time to look to treating humans. An emerging body of scientific studies from all over the world -- including a cardiac study under way in Miami and a pediatric ACL (anterior cruciate ligament) study at the Harvard-affiliated Children's Hospital of Boston -- is showing that using a patient's own stem cells can prompt the growth of new muscle, from the knee to the heart. And the precursor step, using platelet-rich plasma for injuries, is on the verge of becoming mainstream. Adult stem cells, particularly mesenchymal cells that come from muscle, bone and fat, are cells with a powerful ability to replicate and not a lot of personal identity. They easily take on the characteristics of surrounding cells and they tend to grow quickly once they get there. Ultrasounds of Vazquez's horses, for example, show regeneration of muscle in four to six weeks. The final product is this cartilage-like tissue grown around the scaffolding by NIH scientists. Tuan says the tissue resembles the human version, but may not be mechanically sound -- yet. Courtesy NIAMS Adult stem cells can be found all over the body, in bone and marrow. Tuan says they're also found in tonsils and in the placenta and umbilical cord, which suggest that the discarded body parts can be stored for later use. Because researchers are using autologous cells -- from the patient's own body -- the research is not controversial. No one has challenged the ethics or funding of adult stem cell research the way embryonic stem cell studies have been challenged. And because adult stem cells are native to the patient's own body, the chances of a patient rejecting them are slim to none. Tuan and his team have been able to coach adult stem cells to form muscle and disks using goo from the small intestine and a polymer scaffold to tell cells how to grow. But, he cautions, the primitive structures aren't ready to go into humans. "After a few weeks (of lab growth), it will turn into something that resembles a tendon, but it has to be the mechanical equivalent and we don't know that we're there," Tuan says. "Stem cells are very promising, but what they do for horses may not work so well for humans because humans are the hardest animal to rebuild." Once they're perfected, Tuan sees a day when the tendons will change the dreaded surgery for torn anterior cruciate ligaments that sideline up to a quarter-million people in the United States and Canada every year. "Often, that injury is a complete tear -- the ligament is snapped in two and the ends ball up and even if you untangle them and pull them together, they won't heal," he says. "So they take part of the patella tendon, which is short and tough, and stretch it and staple it to the bones. So not only is your ACL not working too well and you have to stretch it out, but your knee hurts like crazy." "If we can learn to grow a tendon that works right, or figure out how to make the ACL heal back together, we can save a lot of people a lot of pain," he says. In fact, doctors are already treating people with adult stem cells. Bone marrow transplants for cancer patients are basically stem cell therapy. But the marrow often comes from other people, and its primary purpose is to boost a weakened immune system, not to generate tissue. And treating with platelet-rich plasma -- a blood product made by spinning a patient's blood in a centrifuge to concentrate the platelets -- is already in limited use and is becoming more widely accepted as a safe therapy. PRP is routinely used in cardiac surgery, where applying it to a cut sternum before closing has been shown to cut the infection rate in half. The plasma has growth factors that also promote healing. "PRP helps recruit stem cells to the injury," says Dr. Allan Mishra, who has used PRP on its own and as part of surgery in sports injuries -- including treating tennis elbow and getting Stanford football player James McGillicuddy's patellar tendon to heal after his second surgery. "The body knows how to heal itself -- we're speeding up and concentrating the process." Last year, Mishra wrapped up a study where he used platelet-rich plasma to treat the 20 worst tennis-elbow injuries he'd culled from more than 100 volunteers. "Ninety-three percent got better with a single injection and stayed better for two years," Mishra says. The treatments are about one-tenth of the cost of surgery, or about $2,000 to $2,500, he says. The patient's blood is drawn, centrifuged by a specialist called a perfusionist, and injected, all in one visit. "I will guess that five years from now, insurance companies won't authorize surgery until the patient has tried and failed at PRP." The obvious next step is to isolate the stem cells and send them to work, both inside and outside the body, researchers say. "PRP is reparative. Stem cells are regenerative," says Angela Nava, a perfusionist who processes both animal and human blood for PRP, stem cell and other procedures. But getting from animals to humans is going to take a lot more research, according to Dr. Thomas Rando, an associate professor of neurology at Stanford University School of Medicine. Rando studies the body's signaling systems that tell stem cells what to do. "We don't always know how stem cells, when injected into some tissues, work their magic," Rando said. "Veterinarians don't go back and study the horse's tendons to figure out what the stem cells did to promote healing." "There are all kinds of ways stem cells could work. If we could understand how they are actually promoting better function of the tissue, we might be able to further improve their therapeutic effects," he adds. Stem cell treatment is not without risks, researchers say. The worst-case scenario is that the stem cells could cause cancer -- or become cancerous themselves. "You're putting in cells that want to grow. That has to be under control," Rando says. "Or we can end up with cancer." Tuan also says that researchers don't entirely trust stem cells and their ability to adapt and grow. "There's a nagging feeling that there's a cancer stem cell, that when it's agitated by exposure to carcinogens or radiation or something, it goes nuts, and that we can't identify it from the other stem cells," he says. "How do you find this bad boy and pull him out? "And there's a nagging worry it's the same cell. We only know these cells by what they've done, and by the time they've become cancer, it's too late."
Matthew McConaughey's unique fertilizer - the placenta from his son's birth
Actor Matthew McConaughey says he will plant the placenta from the birth of his son in an orchard.
Did 'burrowing' placenta give us big brains?
A hormone which allows the placenta to push into the wall of the uterus in some primates might also have played a key role in brain evolution (full text available to subscribers)
BBtv Animation: "Placenta" and "Papiroflexia," by Joaquin Baldwin
Today on Boing Boing tv, two short works from the young Paraguay-born animator and web designer Joaquin Baldwin, now a student at UCLA in Los Angeles. First, Papiroflexia, "An origami tale of a skillful paper folder who could shape the world with his hands." Next, Placenta, an "autobiographical film using photography, motion graphics and rotoscoped video." Link to Boing Boing tv post with discussion, downloadable video, and BBtv podcast subscription instructions. Previously on Boing Boing tv: Joaquin Baldwin's short, "Sebastian's Voodoo."...
and are licensed under the GNU Free Documentation License.
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