Peptic ulcer

Peptic ulcer is usually a non-malignant ulcer of the stomach (called gastric ulcer) or duodenum (called duodenal ulcer). About 4 % of gastric ulcers are caused by malignant tumour, which is why ulcers of stomach are controlled. Duodenal ulcers are non-malignant. By far most instances are now known to be due to Helicobacter pylori, a spiral-shaped bacterium that lives in the acid environment of the stomach. These ulcers can also be caused or worsened by drugs such as Aspirin and other NSAIDs.

Treatment

Younger patients with ulcer-like symptoms are often treated with antacids or H2 antagonists before EGD is undertaken. Bismuth compounds may actually reduce or even clear organisms.

Related Topics:
Antacid - H2 antagonist - Bismuth

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When H. pylori infection is present, the most effective treatments are combinations of antibiotics (Erythromycin, Ampicillin, Tetracycline, Metronidazole) and proton pump inhibitors (PPI). In the absence of H. pylori, long-term higher dose PPIs are often used.

Related Topics:
Erythromycin - Ampicillin - Tetracycline - Metronidazole - Proton pump inhibitor

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Treatment of Helicobacter usually leads to clearing of infection, relief of symptoms and eventual healing of ulcers. Recurrence of infection can occur and retreatment may be required, if necessary with other antibiotics.

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