Paul Ehrlich

:For the American butterfly and overpopulation specialist, see Paul R. Ehrlich.

Magic Bullet

His life is depicted in the movie The Magic Bullet, which focused on Salvarsan® (arsphenamine, "compound 606"), his cure for syphilis. His work raised the existence of the blood-brain barrier.

Related Topics:
The Magic Bullet - Salvarsan - Blood-brain barrier

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The "magic bullet" concept comes from the experience of 19th century German chemists with selectively staining tissues for histological examination, and in particular, selectively staining bacteria (Ehrlich was an exceptionally gifted histological chemist, and invented the precursor technique to Gram staining bacteria). Ehrlich figured that if a compound could be made that selectively targeted a disease causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. Hence, a "magic bullet" would be created that killed only the organism targeted.

Related Topics:
Magic bullet - 19th century - Histological - Bacteria - Chemist - Gram stain - Disease - Organism - Toxin

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A problem with the use of the magic bullet concept as it emerged from its histological roots is that people confused the dye with the agent of tissue selectivity and antibiotic activity. Prontosil, a sulfonamide, whose active component is sulfanilamide, is a classic example of the fact that color is not essential to antibiotic activity.

Related Topics:
Dye - Tissue - Antibiotic - Prontosil - Sulfonamide - Color

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The concept of a "magic bullet" was fully realized with the invention of monoclonal antibodies.

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