Parkinson's disease

Parkinson's disease (PD; paralysis agitans) is a neurodegenerative disease of the substantia nigra (an area in the basal ganglia of the brain). The disease was first discovered and its symptoms documented in 1817 (An Essay on the Shaking Palsy) by the British physician Dr. James Parkinson; the associated biochemical changes in the brain of patients were identified in the 1960s. Some genes were identified only recently; others remain unknown.

References

• {{note|PDmousemodel}} {{Journal reference issue | Author=Eliezer Masliah, Edward Rockenstein, Isaac Veinbergs, Margaret Mallory, Makoto Hashimoto, Ayako Takeda, Yutaka Sagara, Abbyann Sisk, Lennart Mucke | Title= Dopaminergic Loss and Inclusion Body Formation in alpha-Synuclein Mice: Implications for Neurodegenerative Disorders | Journal=Science | Volume=287 | Issue=5456 | Year=2000 | Pages= 1265–1269 }} PMID 10678833

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