Osteogenesis imperfecta

Osteogenesis imperfecta (OI), commonly known as brittle bone disease, is a group of genetic bone disorders. People with OI do not produce enough good quality collagen to produce healthy, strong bones. Collagen is an important protein and without a good enough supply the bones are weak and break very easily.

Related Topics:
Genetic - Bone - Collagen - Protein

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As a genetic disorder, OI is a autosomal dominant defect. Most people with OI receive it from a parent but it can also be an individual (de novo or "sporadic") mutation.

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