Osteoblast

An osteoblast (from the Greek words for "bone" and "to build") is a mononucleate cell which produces a protein that produces osteoid.

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Osteoblasts arise when osteoprogenitor cells (mesenchymal cells), which are located near all bony surfaces and within the bone marrow, differentiate under the influence of growth factors, such as fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-?) and other bone morphogenetic proteins (BMPs).

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In addition to osteoid, osteoblasts also secrete enzymes which facilitate mineral deposition within osteoid matrices. They are also responsible for regulating the activity of osteoclasts via soluble mediators.

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Osteoblasts that become trapped in the bone matrix become osteocytes.

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Greek: The noun Greek refers to:...

Bone: Bone is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bones support body structures, protect internal organs, and (in conjunction with muscles) facilitate movement; are also involved with cell formation, calcium metabolism, and mineral storage. The bones of an anima...

Cell: A cell is a single unit or compartment, enclosed by a border or wall. A cell is usually part of a larger structure. More specific meanings depend on the context in which the work is used....