Nucleophilic substitution

In chemistry, nucleophilic substitution is a class of substitution reaction in which a electron-rich nucleophile attacks a molecule and replaces a group or atom, called the leaving group. It is a fundamental class of reaction in organic chemistry, where the reaction occurs at a carbon centre, but nucleophilic substitutions are also well known in inorganic covalent compounds too.

References

• {{Note|1}} L. G. Wade, Organic Chemistry, 5th ed., Prentice Hall, Upper Saddle RIver, New Jersey, 2003.
• {{Note|2}} J. March, Advanced Organic Chemistry, 4th ed., Wiley, New York, 1992.
• {{Note|3}} J. P. Clayden, N. Greeves, S. Warren, P. D. Wothers, Organic Chemistry, Oxford University Press, Oxford, UK, 2001.
• {{Note|4}} S. R. Hartshorn, Aliphatic Nucleophilic Substitution, Cambridge University Press, London, 1973.
• {{Note|5}} R. A. Rossi, R. H. de Rossi, Aromatic Substitution by the S_RN1 Mechanism, ACS Monograph Series No. 178, American Chemical Society, 1983.