Malcolm Brenner

Malcolm K. Brenner is a British clinical scientist working mostly in the field of gene therapy and immunotherapy applied to malignancy.

Related Topics:
Gene therapy - Immunotherapy

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He received his medical degree and subsequent Ph.D. from Cambridge University, England. He became part of the UK brain-drain in the 1970s, when he left the UK to work in St. Jude Children's Research Hospital in Memphis.

Related Topics:
Cambridge University - England - UK - Brain-drain - 1970s - St. Jude Children's Research Hospital - Memphis

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There, he conducted one of the first human gene therapy studies when he transduced bone-marrow stem cells with a retroviral vector with the intention of marking them to study their survival and fate. This seminal study demonstrated that engrafted bone marrow stem cells contribute to long-term hematopoiesis and also that contaminating tumor cells in autografts can cause relapse.

Related Topics:
Bone-marrow - Stem cell - Retroviral vector - Hematopoiesis - Autograft - Relapse

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More recently, his group has become interested in the genetic-modification of T-cells for cancer therapy, cancer vaccines and monoclonal antibodies.

Related Topics:
T-cells - Cancer - Cancer vaccine - Monoclonal antibodies

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He currently works in the Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.

Related Topics:
Baylor College of Medicine - Houston

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