Magnetic resonance imaging

Magnetic resonance imaging (MRI) - also called magnetic resonance tomography (MRT) - is a method of creating images of the inside of opaque organs in living organisms as well as detecting the amount of bound water in geological structures. It is primarily used to demonstrate pathological or other physiological alterations of living tissues and is a commonly used form of medical imaging. MRI has also found many niche applications outside of the medical and biological fields such as rock permeability to hydrocarbons and certain non-destructive testing methods such as produce and timber quality characterization http://www.mri.cl/index.pl/industrial_stud#355.

Application

In clinical practice, MRI is used to distinguish pathologic tissue (such as a brain tumor) from normal tissue. One of the advantages of an MRI scan is that, according to current medical knowledge, it is harmless to the patient. It utilizes strong magnetic fields and non-ionizing radiation in the radio frequency range. Compare this to CT scans and traditional X-rays which involve doses of ionizing radiation and may increase the chance of malignancy, especially in children receiving multiple examinations.

Related Topics:
Brain tumor - CT scans - Traditional X-rays - Ionizing radiation

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While CT provides good spatial resolution (the ability to distinguish two structures an arbitrarily small distance from each other as separate), MRI provides comparable resolution with far better contrast resolution (the ability to distinguish the differences between two arbitrarily similar but not identical tissues). The basis of this ability is the complex library of pulse sequences that the modern medical MRI scanner includes, each of which is optimized to provide image contrast based on the chemical sensitivity of MRI.

Related Topics:
Spatial resolution - Contrast resolution

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For example, with particular values of the echo time (TE) and the repetition time (TR), which are basic parameters of image acquisition, a sequence will take on the property of T2 weighting. On a T2 weighted scan, water and fluid-containing tissues are bright (most modern T2 sequences are actually fast T2 sequences, in which case fat is also bright). Damaged tissue tends to develop edema, which makes a T2 weighted sequence sensitive for pathology, and generally able to distinguish pathologic tissue from normal tissue. With the addition of an additional radio frequency pulse and some more manipulation of the magnetic gradients, a T2 weighted sequence can be converted to a FLAIR (fluid light attenuation inversion recovery) sequence, in which free water now is dark, but edematous tissues remain bright. This sequence, in particular, is currently the most sensitive way to evaluate the brain for changes of multiple sclerosis.

Related Topics:
Edema - Multiple sclerosis

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The typical MRI examination typically consists of 5-20 sequences, each of which are chosen to provide a particular type of information about the subject tissues. This information is then synthesized by the interpreting physician.

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Safety

The presence of a ferromagnetic foreign body (such as shell fragments) in the subject, or a metallic implant (like surgical prostheses, or pacemakers) can present a (relative or absolute) contraindication towards MRI scanning: interaction of the magnetic and radiofrequency fields with such an object can lead to: trauma due to shifting of the object in the magnetic field, thermal injury from radiofrequency induction of heating of the object, or failure of an implanted device.

Related Topics:
Ferromagnetic - Shell - Surgical prostheses - Pacemaker - Contraindication

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As a result of the very high strength of the magnetic field needed to produce scans (frequently up to 60,000 times the earth's own magnetic field effects), there are several incidental safety issues addressed in MRI facilities. Missile-effect accidents, where ferromagnetic objects are attracted to the center of the magnet, have resulted in injury and death. It is for this reason that ferrous objects and devices are prohibited in proximity to the MRI scanner, with nonmagnetic "MRI-safe" versions of many of these objects typically retained by the scanning facility. Contrary to expectations, the magnet is energized at all times, even when it is not in use. Because of this, floor cleaning machines are often a victim of the magnet. An emergency shut-down of the magnet, an operation known as a 'quench', is costly and involves dumping liquid helium from the device. The sudden expansion of the escaping cold helium liquid into its gaseous form, and the displacement of oxygen is a hazard of it own. Because of this, if a ferromagnetic item does become lodged in the magnet, it often is carefully removed with a winch.

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Many safety issues, including the potential for biostimulation device interference, movement of ferromagnetic bodies and incidental localized heating have been addressed in the American College of Radiology's 'White Paper on MR Safety' which was originally published in 2002 and expanded in 2004.

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Specialised MRI scans

Diffusion MRI

Diffusion MRI measures the diffusion of water molecules in biological tissues. In an isotropic medium (inside a glass of water for example) water molecules naturally move according to Brownian motion. In biological tissues however, the diffusion is very often anisotropic. For example a molecule inside the axon of a neuron has a low probability to cross a myelin membrane. Therefore the molecule will move principally along the axis of the neural fiber. Conversely if we know that molecules locally diffuse principally in one direction we can make the assumption that this corresponds to a set of fibers.

Related Topics:
Diffusion MRI - Diffusion - Isotropic - Brownian motion - Anisotropic - Axon - Myelin

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The recent development of Diffusion Tensor Imaging (DTI) enables diffusion to be measured in multiple directions (currently up to 99) and the Fractional Anisotropy in each direction to be calculated for each voxel. This enables researchers to make axonal maps to examine the structural connectivity of different regions in the brain (tractography) or to examine areas of neural degeneration and demyelinaton in diseases like Multiple Sclerosis.

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Another application of diffusion MRI is diffusion-weighted imaging (DWI). Following an ischemic stroke, brain cells die. It is speculated that resultant areas of restricted diffusion are detectable. This finding appears within 5-10 minutes of the onset of stroke symptoms (as compared with computed tomography, which often does not detect changes of acute infarct for up to 4-6 hours) and remains for up to two weeks. As such, DWI sequences are extraordinarily sensitive for acute stroke.

Related Topics:
Diffusion-weighted imaging - Stroke - Computed tomography

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Finally, it has been proposed that diffusion MRI may be able to detect minute changes in extracellular water diffusion and therefore could be used as a tool for fMRI. The nerve cell body enlarges when it conducts an action potential, hence restricting extracellular water molecules from diffusing naturally. Although this process works in theory, evidence is only moderately convincing. If it could be made to work, diffusion fMRI would not experience the temporal lag seen in BOLD fMRI.

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Magnetic resonance angiography

Magnetic resonance angiography (MRA) is used to generate pictures of the arteries, in order to evaluate them for stenosis (abnormal narrowing) or aneurysms (vessel wall dilatations, at risk of rupture). The main use of MRA is to evaluate the arteries of the neck and brain, the thoracic and abdominal aorta, and the kidneys. A variety of techniques can be used to generate the pictures, such as administration of a paramagnetic contrast agent (such as gadolinium) or using a technique known as "flow-related enhancement" (e.g. 2D and 3D time-of-flight sequences), where the only signal on an image is due to blood which has recently moved into that plane. MRV is a similar procedure that is used to image veins. In this method the tissue is now excited dorsally while signal is gathered in the plane immediately ventral to the excitation plane, and thus imaging the venous blood which has recently moved from the excited plane.

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Magnetic resonance spectroscopy

Magnetic resonance spectroscopy (MRS), also known as MRSI (MRS Imaging) and Volume Selective NMR Spectroscopy, is a technique which combines the spatially-addressable nature of MRI with the spectroscopically-rich information obtainable from nuclear magnetic resonance (NMR). That is to say, MRI allows one to study a particular region within an organism or sample, but gives relatively little information about the chemical or physical nature of that region--its chief value is in being able to distinguish the properties of that region relative to those of surrounding regions. MR spectroscopy, however, provides a wealth of chemical information about that region, as would an NMR spectrum of that region.

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Functional MRI

Functional MRI (fMRI) measures signal changes in the brain that are due to changing neural activity. The brain is scanned at low resolution but at a rapid rate (typically once every 2-3 seconds). Increases in neural activity cause changes in the MR signal via a mechanism called the BOLD (blood oxygen level-dependent) effect. Increased neural activity causes an increased demand for oxygen, and the vascular system actually overcompensates for this, increasing the amount of oxygenated hemoglobin ("haemoglobin" in British English) relative to deoxygenated hemoglobin. Because deoxygenated hemoglobin attenuates the MR signal, the vascular response leads to a signal increase that is related to the neural activity. The precise nature of the relationship between neural activity and the BOLD signal is a subject of current research. The BOLD effect also allows for the generation of high resolution 3D maps of the venous vasculature within neural tissue.

Related Topics:
Functional MRI - Brain - Neural - Blood - Oxygen - Vascular - Hemoglobin

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While BOLD signal is the most common method employed for neuroscience studies in human subjects, the flexible nature of MR imaging provides means to sensitize the signal to other aspects of the blood supply. Alternative techniques employ arterial spin labeling (ASL) or weight the MRI signal by cerebral blood flow (CBF) and cerebral blood volume (CBV). The CBV method requires injection of a class of MRI contrast agents that are now in human clinical trials. Because this method has been shown to be far more sensitive than the BOLD technique in pre-clinical studies, it may potentially expand the role of fMRI in clinical applications. The CBF method provides more quantitative information than the BOLD signal, albeit at a significant loss of detection sensitivity.

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Interventional MRI

Because of the lack of harmful effects on the patient and the operator, MR is well suited for "interventional radiology", where the images produced by an MRI scanner are used to guide a minimally invasive procedure intraoperatively and/or interactively. However, the non-magnetic environment required by the scanner, and the strong magnetic radiofrequency and quasi-static fields generated by the scanner hardware require the use of specialized instruments. Often required is the use of an "open bore" magnet which permits the operating staff better access to patients during the operation. Such open bore magnets are often lower field magnets, typically in the 0.2 tesla range, which decreases their sensitivity but also decreases the Radio Frequency power potentially absorbed by the patient during a protracted operation. Higher field magnet systems are beginning to be deployed in intraoperative imaging suites, which can combine high-field MRI with a surgical suite and even CT in a series of interconnected rooms. Specialty high-field interventional MR devices, such as the IMRIS system, can actually bring a high-field magnet to the patient within the operating theatre, permitting the use of standard surgical tools while the magnet is in an adjoining space.

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Radiation Therapy Simulation

Because of MRI's superior imaging of soft tissues, it is now being utilized to specifically locate tumors within the body in preparation for radiation therapy treatments. For therapy simulation, a patient is placed in specific, reproducible, body position and scanned. The MRI system then computes the precise location, shape and orientation of the tumor mass, correcting for any spatial distortion inherent in the system. The patient is then marked or tatooed with points which, when combined with the specific body position, will permit precise triangulation for radiation therapy.

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Current Density Imaging

Current density imaging is a subbranch of MRI that endeavors to use the phase information from the MRI images to reconstruct current densities within a subject. Current density imaging works because electrical currents generate magnetic fields, which in turn affect the phase of the magnetic dipoles during an imaging sequence. To date no successful CDI has been performed using biological currents, however several studies have been published which involve applied currents through a pair of electrodes.

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