Lymphoma

Lymphoma is a general term for malignancies of lymphocytes or, more rarely, of histiocytes. Collectively, these cell types form the reticuloendothelial system and circulate in the vessels of the lymphatic system.

Classification

The Working Formulation, published in 1982, is primarily descriptive but remains the most widely used classification of non-Hodgkin lymphoma today.

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• Low Grade
• Malignant Lymphoma, small lymphocytic (chronic lymphocytic leukemia)
• Malignant Lymphoma, follicular, predominantly small cleaved cell
• Malignant Lymphoma, follicular, mixed (small cleaved and large cell)
• Intermediate Grade
• Malignant Lymphoma, follicular, predominantly large cell
• Malignant Lymphoma, diffuse, small cleaved cells
• Malignant Lymphoma, diffuse, mixed (small and large cells)
• Malignant Lymphoma, diffuse large cells
• High Grade
• Malignant Lymphoma, large cell, immunoblastic
• Malignant Lymphoma, lymphoblastic
• Malignant Lymphoma, small non-cleaved cells (Burkitt's lymphoma)
• Miscellaneous
• Composite
• Mycosis fungoides
• Histiocytic
• Extramedullary plasmacytoma
• Unclassifiable

The WHO Classification is the latest classification of lymphoma, published by the World Health Organization in 2001. This classification attempts to classify lymphomas by cell type, i.e. the normal cell type that most closely resembles the tumour. They are classified in three large groups: the B cell tumours, the T cell and natural killer cell tumours, Hodgkin lymphoma, and other minor groups:

Related Topics:
World Health Organization - B cell - T cell - Natural killer cell - Hodgkin lymphoma

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• Mature B Cell Neoplasms
• Chronic lymphocytic leukemia/small lymphocytic lymphoma
• B-cell prolymphocytic leukaemia
• Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
• Splenic marginal zone lymphoma
• Plasma cell neoplasms
• Plasma cell myeloma
• Plasmacytoma
• Monoclonal immunoglobulin deposition diseases
• Heavy chain diseases
• Extranodal marginal zone B cell lymphoma (MALT lymphoma)
• Nodal marginal zone B cell lymphoma
• Follicular lymphoma
• Mantle cell lymphoma
• Diffuse large B cell lymphoma
• Mediastinal (thymic) large B cell lymphoma
• Intravascular large B cell lymphoma
• Primary effusion lymphoma
• Burkitt lymphoma/leukemia
• lymphomatoid granulomatosis
• Mature T cell and Natural Killer (NK) Cell Neoplasms
• T cell prolymphocytic leukemia
• T cell large granular lymphocytic leukemia
• Agressive NK cell leukemia
• Adult T cell leukemia/lymphoma
• Extranodal NK/T cell lymphoma, nasal type
• Enteropathy-type T cell lymphoma
• Hepatosplenic T cell lymphoma
• Blastic NK cell lymphoma
• Mycosis fungoides/Sezary syndrome
• Primary cutaneous CD30-positive T cell lymphoproliferative disorders
• Primary cutaneous anaplastic large cell lymphoma
• Lymphomatoid papulosis
• Angioimmunoblastic T cell lymphoma
• Peripheral T cell lymphoma, unspecified
• Anaplastic large cell lymphoma
• Hodgkin Lymphoma
• Nodular lymphocyte-predominant Hodgkin lymphoma
• Classical Hodgkin lymphoma
• Nodular sclerosis
• Mixed cellularity
• Lymphocyte-rich
• Lymphocyte depleted
• Immnuodeficiency-Associated Lymphoproliferative Disorders
• Associated with a primary immune disorder
• Associated with the Human Immunodeficiency Virus (HIV)
• Post-transplant
• Associated with Methotrexate therapy
• Histiocytic and Dendritic Cell Neoplasms
• Histiocytic sarcoma
• Langerhans cell histiocytosis
• Langerhans cell sarcoma
• Interdigitating dendritic cell sarcoma/tumour
• Follicular dendritic cell sarcoma/tumour
• Dendritic cell sarcoma, unspecified