Irwin Rose

Irwin A. Rose (born 16 July 1926 in NY) is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Related Topics:
16 July - 1926 - Biologist - Aaron Ciechanover - Avram Hershko - Nobel Prize in Chemistry - Ubiquitin - Protein degradation

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Rose received his B.S. in 1948 and his Ph.D. in biochemistry in 1952, both from the University of Chicago. He is currently a specialist at the Department of Physiology and Biophysics of the College of Medicine at the University of California, Irvine.

Related Topics:
1948 - 1952 - University of Chicago - University of California, Irvine

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Irwin (Ernie) had several graduate students while at the Fox Chase Cancer Center in Philadelphia, where the groundbreaking Ub work was done. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, Judith Klinman, a pioneer in proton tunneling in proteins, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.

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Ernie would frequently tour the lab, with a harmonica, when Avram and Aaron were there working in the summer with Keith and Art.

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