HSC

HSC may refer to

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• Home Shopping Club, the old name of the Home Shopping Network
• Higher School Certificate, the final examination in secondary school education in New South Wales, Australia.
• Higher Secondary (School) Certificate, the "certificate" given to students passing out of higher secondary school/junior college in Bangladesh, and also in Maharashtra, India. Also refers to the final examination taken by thousands of students of Grade 12 (Called Standard 12 in India) in Maharashtra
• Hematopoietic stem cell, stem cells found in the bone marrow.
• Hospital for Sick Children, a pediatric hospital in Toronto, Canada.