Hepatitis C

Hepatitis C is a form of hepatitis (liver inflammation) caused by a virus, the Hepatitis C virus (HCV). Before the virus was discovered, in 1989, the syndrome was initially referred to as a "non-A-non-B hepatitis". In about 15% of cases, hepatitis C infection is acute, meaning it is cleared spontaneously by the body and there are no long-term consequences. Unfortunately, in the majority of cases (85%), the infection becomes chronic and may damage the liver over many years.

Hepatitis C co-infection with HIV

Approximately 40% of U.S. patients infected with HIV are also infected with the hepatitis C virus (HCV), mainly because both viruses share the same routes of transmission. HCV is one of most important causes of chronic liver disease in the U.S. It has been demonstrated in clinical studies that HIV infection causes a more rapid progression of chronic hepatitis C to cirrhosis and liver failure in HIV-infected persons. This is not to say treatment is not an option for those living with co-infection. The APRICOT international trial indicated that a svr (sustained viral response) was high in those with the genotype 2 & 3. Less favorable results where associated with genotype 1, however it became evident that should treatment with pegylated ribivirin-interferon not return a 2 log viral reduction after 12 weeks, the chance of treatment success is less than 1%.

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