Helicobacter pylori
Helicobacter pylori is a Eubacterium that infects the mucus lining of the human stomach. Many peptic ulcers and some types of gastritis are caused by H. pylori infection, although most humans who are infected will never develop symptoms. This bacterium lives in the human stomach exclusively and is the only known organism that can thrive in that highly acidic environment. It is helix-shaped (hence the name helicobacter) and can literally screw itself into the stomach lining to colonize.
References
- Marshall BJ. Unidentified curved bacillus on gastric epithelium in active chronic gastritis. Lancet 1983;1((8336):1273-1275. PMID 6134060.
- Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration. Lancet 1984;1(8390):1311-1315. PMID 6145023.
- Helicobacter pylori in peptic ulcer disease. NIH Consensus Statement Online 1994 Jan 7-9.12(1):1-23. Cited 2004 Dec 21. Fulltext.
- Helicobacter pylori and peptic ulcer. Centers for Disease Control and Prevention. Cited 2004 Dec 21. Fulltext.
- Blaser MJ. An Endangered Species in the Stomach. Scientific American 2005;292(2):38-45. partial text. PMID 15715390.
- Logan RPH, Walker MM. Clinical review: ABC of the upper gastrointestinal tract. Epidemiology and diagnosis of Helicobacter pylori infection. BMJ 2001;323:920-922. Full text. PMID 11668141.
- Tsuji S, Kawai N, Tsujii M, Kawano S, Hori M. Review article: inflammation-related promotion of gastrointestinal carcinogenesis - a perigenetic pathway. Aliment Pharmacol Ther 2003;18(Suppl 1):82-9. PMID 12925144.
- Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Memet S, Huerre MR, Coyle AJ, DiStefano PS, Sansonetti PJ, Labigne A, Bertin J, Philpott DJ, Ferrero RL. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nature Immunol 2004;5:1166-74. Fulltext. PMID 15489856.
- Galan MV, Kishan AA, Silverman AL. Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. Dig Dis Sci. 2004 Aug;49(7-8):1088-90. PMID 15387326
- Konturek JW. Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer. J Physiol Pharmacol. 2003 Dec;54 Suppl 3:23-41. Fulltext PMID 15075463
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