Grubbs' Catalyst

Grubbs' Catalyst is named after the chemist by whom it was first synthesized, Robert H. Grubbs. There are two generations of the catalyst, as shown on the right. In contrast to other olefin metathesis catalysts, Grubbs' Catalysts tolerate other functional groups in the alkene and are compatible with a wide range of solvents4. For these reasons, Grubbs' Catalysts are extraordinarily versatile.

References

• Schwab, P.; Grubbs, R. H.; Ziller, J. W. Journal of the American Chemical Society, 1996, 118, 100-110.
• Louie, J.; Grubbs, R. H. Organometallics, 2002, 21, 2153-2164.
• Scholl, M.; Ding, S.; Lee, C. W.; Grubbs, R. H. Organic Letters, 1999, 1, 953-956.
• Trnka, T. M.; Grubbs, R. H. Accounts of Chemical Research, 2001, 34, 18-29.
• Bonser, K. http://science.howstuffworks.com/self-healing-spacecraft1.htm
• Grubbs, R.H. Handbook of Metathesis; Wiley-VCH, Germany, 2003.
• Grubbs, R.H.; Trnka, T.M.: Ruthenium-Catalyzed Olefin Metathesis in "Ruthenium in Organic Synthesis" (S.-I. Murahashi, Ed.), Wiley-VCH, Germany, 2004.