Grignard reagent
A Grignard Reagent is an alkyl- or aryl- magnesium halide. This reagent is important in the synthesis of carbon-carbon bonds in the Grignard reaction. Grignard reagents undergo reactions with compounds containing carbonyl groups. These reactions create alcohols.
Coupling reaction
A Grignard reagent can also be involved in a coupling reaction. For example nonylmagnesium bromide (CAS registry number 39691-62-8) reacts with a aryl chloride to a nonyl benzoic acid (CAS registry number 38289-46-2). An iron catalyst is used and not a expensive palladium catalyst such as used in Heck reactions. Acac stands for acetylacetonate.
Related Topics:
Coupling reaction - CAS registry number - Palladium - Heck reaction - Acetylacetonate
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~ Table of Content ~
| ► | Introduction |
| ► | Nucleophilic addition reactions |
| ► | Coupling reaction |
| ► | references |
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