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Fischer indole synthesis


 

The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was discovered in 1883 by Hermann Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.

Related Topics:
Chemical reaction - Aromatic - Heterocycle - Indole - Phenylhydrazine - Aldehyde - Ketone - Acid - 1883 - Hermann Emil Fischer - Antimigraine - Triptan

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The choice of acid catalyst is very important. Bronsted acids such as HCl, H2SO4, and polyphosphoric acid have been used successfully. Lewis acids such as boron trifluoride, zinc chloride, iron chloride, and aluminum chloride are also useful catalysts.

Related Topics:
Bronsted acid - HCl - H2SO4 - Polyphosphoric acid - Lewis acid - Boron trifluoride - Zinc chloride - Iron chloride - Aluminum chloride

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Fischer indole synthesis: Reaction mechanism ►

~ Table of Content ~

►Introduction
►Reaction mechanism
►Buchwald modification
►References
►See also

 

 

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