Fentanyl

Fentanyl is an opioid analgesic, first synthesized in Belgium in the late 1950s, with an analgesic potency of about 80 times that of morphine. It was introduced into medical practice in the 1960s as an intravenous anesthetic under the trade name of Sublimaze. Fentanyl has an LD50 of 3.1 milligrams/kg. Fentanyl is a Schedule II drug.

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The pharmaceutical industry has developed several analogues of fentanyl:

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• alfentanil (Alfenta), an ultra-short (5-10 minutes) acting analgesic,
• sufentanil (Sufenta), a potent analgesic (15 to 10 times more potent than fentanyl) for use in heart surgery.
• remifentanil, currently the shortest acting opioid, has the benefit of rapid offset, even after prolonged infusions.
• carfentanil (Wildnil) is an analogue of fentanyl with an analgesic potency 10,000 times that of morphine and is used in veterinary practice to immobilize certain large animals.

Opioid: An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. There are four broad classes of opioids: endogenous opioid peptides, produced in the body; opium alkaloids, such as morphine (the prototypical opioid) and codeine; semi-s...

Analgesic: An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia (literally, "absence of pain"). Analgesic drugs act in various ways on the peripheral and central nervous system; they include paracetamol (acetaminophen), the no...

Belgium: The Kingdom of Belgium (Dutch: Koninkrijk Belgi?, French: Royaume de Belgique, German: K?nigreich Belgien) is a Federal state in a continuous process of devolution. It is a developed country in North-Western Europe that is bordered by the Netherlands, Germany, Luxembourg, France, and the North Sea. ...