Casein

:See Casein paint for information about casein usage in artistic painting.

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Casein is the predominant phosphoprotein found in fresh milk. When coagulated with rennet, casein is sometimes called paracasein. British terminology, on the other hand, uses the term caseinogen for the uncoagulated protein and casein for the coagulated protein. As it exists in milk, it is a salt of calcium.

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Casein is not coagulated by heat. It is precipitated by acids and by rennet, a proteolytic enzyme obtained from the stomachs of calves. The enzyme trypsin can hydrolyze off a phosphate-containing peptone.

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Casein consists of a fairly high number of proline peptides, which do not interact. There are also no disulphide bridges. As a result, it has relatively little secondary structure or tertiary structure. Because of this, it cannot denature. It is relatively hydrophobic, making it poorly soluble in water. It is found in milk as a suspension of particles called casein micelles which show some resemblance with surfactant-type micellae in a sense that the hydrophilic parts reside at the surface. The caseins in the micelles are held together by calcium ions and hydrophobic interactions.

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In addition to being consumed in milk casein is used in the manufacture of adhesives, binders, protective coatings, plastics (such as for knife handles and knitting needles), fabrics, food additives and many other products. It is commonly used by bodybuilders as a slow-digesting source of amino acids.

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The isoelectric point of casein is 4.6. The purified protein is water insoluble. While it is also insoluble in neutral salt solutions, it is readily dispersable in dilute alkalis and in salt solutions such as sodium oxalate and sodium acetate.

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Some people believe that those with autism and Asperger's syndrome may be sensitive to casein and gluten. See more at gluten-free, casein-free diet.

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Phosphoprotein: Phosphoproteins are a group of proteins which are chemically attached to a chemical substance containing phosphoric acid....

Milk: Milk most often means the nutrient fluid produced by the mammary glands of female mammals. It provides the primary source of nutrition for newborns before they are able to digest more diverse foods. It is also processed into dairy products such as cream, butter, yoghurt, ice-cream, gelato, cheese,...

Rennet: Rennet, also called rennin or chymosin (), is an enzyme that is added to milk as the first step in making cheese, or for making junket. The enzyme reacts with κ-casein on the surface of the casein micelle particles in the milk. This in the presence of calcium ions causes the coagulation of th...