Carbon monoxide poisoning

Carbon monoxide (CO) binds very strongly to the iron atoms in haemoglobin, the principal oxygen-carrying compound in blood. The affinity between CO and haemoglobin is 200 times stronger than the affinity between haemoglobin and oxygen.

Physiological role

Carbon monoxide is produced naturally by the body. The breakdown-product of haemoglobin, haeme, is a substrate for the enzyme haeme oxygenase which produces CO and biliverdin. The biliverdin can then be reduced to bilirubin which is excreted by the liver. The CO produced in the brain might act as a neurotransmitter.

Related Topics:
Haeme oxygenase - Biliverdin - Bilirubin

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