Amiloride

Amiloride is an antihypertensive, a potassium-sparing diuretic that was first approved for use in 1967 and helps to treat hypertension and congestive heart failure.

Related Topics:
Antihypertensive - Potassium - Diuretic - 1967 - Hypertension - Congestive heart failure

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Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys. This promotes the loss of sodium and water from the body, but without depleting potassium. The drug is often used in conjunction with thiazide or loop diuretics. Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements.

Related Topics:
Sodium - Distal convoluted tubule - Kidney - Thiazide - Loop diuretic - Hyperkalemia - ACE inhibitor - Spironolactone

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