AD-mix

AD-mix is a chiral ligand and stands for the Asymmetric dihydroxylation mix. This chemical mixture is employed in the Sharpless bishydroxylation reaction. This product is commercially available comes in two variations, AD-mix α and AD-mix β.

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In AD-mix α DHQ2PHAL (top) is the phthalazine adduct with dihydroquinine.

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In AD-mix β; DHQD2PHAL is the phthalazine adduct with dihydroquinidine.

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One mix is used for each one of the enantiomers. The mix further contains:

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• Osmium catalyst potassium osmate K₂OsO₂(OH)₄
• co-oxidant for the regeneration of osmium potassium ferricyanide K₃Fe(CN)₆

Chiral ligand: In chemistry a chiral ligand is a specially adapted ligand used for asymmetric synthesis. This ligand is an enantiopure organic compound which combines with a metal center by chelation to form an asymmetric catalyst. This catalyst engages in a chemical reaction and transfers its chirality to the rea...

Sharpless bishydroxylation: Sharpless bishydroxylation or asymmetric dihydroxylation (AD) is a chemical reaction of an alkene with osmium tetroxide to form a diol (dialcohol). Chiral products can be formed by adding quinine derivatives. A more efficient way to perform this reaction is reoxidise the osmate, which is formed in t...

Phthalazine: Phthalazine, also called benzo-orthodiazine or benzopyridazine, is a heterocyclic organic compound with the molecular formula C8H6N2. It is isomeric with the cinnoline. Phthalazine can be obtained by the condensation of w-tetrabromorthoxylene with hydrazine, or by the reduction of chlorphthalazine w...

AD-mix related Images and Photos (experimental)

A.D.A.C.	M.A.D.	Dracula A.D. 1972	Mix It Up
Risk 2210 A.D. Game	Risk 2210 A.D. Edition	Pancake Mix	Mix 'n' Match I
Tom Mix Print	Tom Mix Print	Dessert Ad II	Scooby-Doo Mix (DVD) (5-Pack)