AD-mix

AD-mix is a chiral ligand and stands for the Asymmetric dihydroxylation mix. This chemical mixture is employed in the Sharpless bishydroxylation reaction. This product is commercially available comes in two variations, AD-mix α and AD-mix β.

Related Topics:
Chiral ligand - Sharpless bishydroxylation

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In AD-mix α DHQ2PHAL (top) is the phthalazine adduct with dihydroquinine.

Related Topics:
Phthalazine - Dihydroquinine

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In AD-mix β; DHQD2PHAL is the phthalazine adduct with dihydroquinidine.

Related Topics:
Phthalazine - Dihydroquinidine

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One mix is used for each one of the enantiomers. The mix further contains:

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• Osmium catalyst potassium osmate K₂OsO₂(OH)₄
• co-oxidant for the regeneration of osmium potassium ferricyanide K₃Fe(CN)₆